Societal Burden And Impact On Health Related Quality Of Life (Hrqol) Of Non-Small Cell Lung Cancer (Nsclc) In Europe.

● Of the 59 publications included in this review, the majority of publications (n=44) reported data on the impact on NSCLC on patients overall HRQoL. — Larsson (2012) and Lee (2011) found that stage III-IV patients reported a significant reduction in global or overall health, as defined by the EORTC QLQ-C30 and WHOQOLBREF respectively, when compared to the general population or healthy controls. — Iyer (2014) found that patients with a later disease stage reported a greater impact of diseaserelated symptoms on their HRQoL, as defined by the LCSS and EORTC-QLQ-C30; while Iyer (2013) found that patients on first-line treatment scored significantly higher on the total score of the FACT-L than those on later lines of treatment, indicating that overall HRQoL decreases with each subsequent line of therapy. 13,14 Emotional and psychological functioning